Trace elements distribution in granitic quartz is highly sensitive to differentiation processes. Abundance of Ti, Ge, Al and Li in primary quartz of Naqadeh granitoids have been studied by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS). Trace elements ratio in quartz exhibits completely different trends in two different Naqadeh granitoid units (more mafic granitoids (MMG) and monzogranites). The variation of Ti/Ge within of quartz in MMG prevents magmatic differentiation as a major role in the evolution of this unit; and Li variation has been produced by different values of amphibole co-crystallization. In other hand, Ti/Ge and Li trends in monzogranites shows important role of magmatic differentiation in their formation. Various Al concentrations between MMG and monzogranites can be ascribed to other factors such as Aluminum Saturation Index.